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- T D Gilmore1
Oncogene volume25,pages 6680–6684 (2006)Cite this article
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Abstract
This article serves as an introduction to the collection of reviews on nuclear factor-kappaB (NF-κB). It provides an overview of the discovery and current status of NF-κB as a research topic. Described are the structures, activities and regulation of the proteins in the NF-κB family of transcription factors. NF-κB signaling is primarily regulated by inhibitor κB (IκB) proteins and the IκB kinase complex through two major pathways: the canonical and non-canonical NF-κB pathways. The organization and focus of articles included in the following reviews are described, as well as likely future areas of research interest on NF-κB.
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Acknowledgements
I thank Melissa Chin for help with artwork in the figures. I also thank D Kalaitzidis, D Starczynowski and members of my lab for comments on the manuscript. I especially thank the authors for their contributions to this review issue, and collectively, we apologize to any researchers who feel that their work was overlooked. Research in my laboratory on NF-κB is currently supported by the National Institutes of Health. For additional, detailed information on NF-κB, the reader is directed to our lab website at www.nf-kb.org.
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Biology Department, Boston University, Boston, MA, USA
T D Gilmore
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Gilmore, T. Introduction to NF-κB: players, pathways, perspectives. Oncogene 25, 6680–6684 (2006). https://doi.org/10.1038/sj.onc.1209954
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DOI: https://doi.org/10.1038/sj.onc.1209954
Keywords
- NF-kappaB
- IkappaB
- IKK
- Rel
- signal transduction
- transcription factor
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